Ontology highlight
ABSTRACT:
SUBMITTER: Reyes-Fernandez PC
PROVIDER: S-EPMC4846362 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20150820 1
1,25 Dihydroxyvitamin D3 (1,25(OH)2 D) increases intestinal Ca absorption when dietary Ca intake is low by inducing gene expression through the vitamin D receptor (VDR). 1,25(OH)2 D-regulated Ca absorption has been studied extensively in the small intestine, but VDR is also present in the large intestine. Our goal was to determine the impact of large intestinal VDR deletion on Ca and bone metabolism. We used transgenic mice expressing Cre-recombinase driven by the 9.5-kb human caudal type homeob ...[more]