Ontology highlight
ABSTRACT:
SUBMITTER: Kinoshita S
PROVIDER: S-EPMC48473 | biostudies-other | 1992 Feb
REPOSITORIES: biostudies-other
Kinoshita S S Akira S S Kishimoto T T
Proceedings of the National Academy of Sciences of the United States of America 19920201 4
Using a DNA probe from the DNA-binding portion of the NF-IL6 gene and an antibody against the DNA-binding domain of NF-IL6, we isolated a gene homologous to NF-IL6 in the DNA-binding and leucine zipper domains. This intronless gene, termed NF-IL6 beta encodes a 269-amino acid protein with a potential leucine zipper structure, and the gene product can bind to the CCAAT homology as well as the viral enhancer core sequence, as in the cases of NF-IL6 and C/EBP. This gene is expressed at an undetecta ...[more]