Ontology highlight
ABSTRACT:
SUBMITTER: Zhao XM
PROVIDER: S-EPMC4849146 | biostudies-other | 2016 Feb
REPOSITORIES: biostudies-other
Zhao X M XM Chen Z Z Zhao J B JB Zhang P P PP Pu Y F YF Jiang S H SH Hou J J JJ Cui Y M YM Jia X L XL Zhang S Q SQ
Cell death & disease 20160211
The pseudokinase mixed lineage kinase domain-like protein (MLKL) is a key component of tumor necrosis factor (TNF)-induced necroptosis and plays a crucial role in necroptosis execution. However, the mechanisms that control MLKL activity are not completely understood. Here, we identify the molecular chaperone Hsp90 as a novel MLKL-interacting protein. We show that Hsp90 associates with MLKL and is required for MLKL stability. Moreover, we find that Hsp90 also regulates the stability of the upstre ...[more]