Ontology highlight
ABSTRACT:
SUBMITTER: Lazelle RA
PROVIDER: S-EPMC4849833 | biostudies-other | 2016 May
REPOSITORIES: biostudies-other
Lazelle Rebecca A RA McCully Belinda H BH Terker Andrew S AS Himmerkus Nina N Blankenstein Katharina I KI Mutig Kerim K Bleich Markus M Bachmann Sebastian S Yang Chao-Ling CL Ellison David H DH
Journal of the American Society of Nephrology : JASN 20151002 5
Tacrolimus is a widely used immunosuppressive drug that inhibits the phosphatase calcineurin when bound to the 12 kDa FK506-binding protein (FKBP12). When this binding occurs in T cells, it leads to immunosuppression. Tacrolimus also causes side effects, however, such as hypertension and hyperkalemia. Previously, we reported that tacrolimus stimulates the renal thiazide-sensitive sodium chloride cotransporter (NCC), which is necessary for the development of hypertension. However, it was unclear ...[more]