Dataset Information

Seasonal variation in cortisol biomarkers in Hispanic mothers living in an agricultural region.

ABSTRACT: Characterization of stress exposure requires understanding seasonal variability in stress biomarkers.To compare acute and chronic stress biomarkers between two seasons in a cohort of rural, Hispanic mothers.Stress questionnaires and cortisol measurements (hair, blood and saliva) were collected in the summer and fall.Cortisol biomarkers were significantly different and stress questionnaires were significantly correlated between seasons.The variability in cortisol and relative stability of questionnaires between seasons may indicate that cortisol responds to subtle stressors not addressed in questionnaires.There are significant differences in stress biomarkers in our cohort between seasons.

SUBMITTER: Smith MN

PROVIDER: S-EPMC4850059 | biostudies-other | 2015

REPOSITORIES: biostudies-other

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Seasonal variation in cortisol biomarkers in Hispanic mothers living in an agricultural region.

Smith Marissa N MN Wilder Carly S CS Griffith William C WC Workman Tomomi T Thompson Beti B Dills Russel R Onstad Gretchen G Vredevoogd Melinda M Vigoren Eric M EM Faustman Elaine M EM

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20150101 5

<h4>Context</h4>Characterization of stress exposure requires understanding seasonal variability in stress biomarkers.<h4>Objective</h4>To compare acute and chronic stress biomarkers between two seasons in a cohort of rural, Hispanic mothers.<h4>Methods</h4>Stress questionnaires and cortisol measurements (hair, blood and saliva) were collected in the summer and fall.<h4>Results</h4>Cortisol biomarkers were significantly different and stress questionnaires were significantly correlated between sea ...[more]

PMID: 26329526

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Project description:BackgroundExisting literature suggests that endocrine measures, including the steroid hormones of cortisol and Dehydroepiandrosterone (DHEA), as well as the DHEA to cortisol ratio in the human hair can be used as promising biomarkers of chronic stress among humans. However, data are limited regarding the validity of these measures as biomarkers of chronic stress among people living with HIV (PLWH), whose endocrine system or hypothalamic pituitary adrenal (HPA) axis may be affected by HIV infection and/or antiretroviral therapy (ART) medications.MethodUsing hair sample data and self-reported survey from 60 PLWH in China, we examined the validity of three endocrine measures among Chinese PLWH using a known-groups validation strategy. High-stress group (n = 30) and low-stress group (n = 30) of PLWH were recruited through individual assessment interviews by a local licensed psychologist. The endocrine measures in hair were extracted and assessed by LC-APCI-MS/MS method. Both bivariate and multivariate analyses were conducted to examine the associations between the endocrine measures and the stress level, and to investigate if the associations differ by ART status.ResultsThe levels of endocrine measures among Chinese PLWH were consistent with existing studies among PLWH. Generally, this pilot study confirmed the association between endocrine measures and chronic stress. The high stress group showed higher level hair cortisol and lower DHEA to cortisol ratio. The higher stress group also reported higher scores of stressful life events, perceived stress, anxiety and depression. Hair cortisol level was positively related to anxiety; DHEA was negatively associated with stressful life events; and the DHEA to cortisol ratio was positively related to stressful life events and perceived stress. ART did not affect the associations between the endocrine measures and stress level.ConclusionsOur findings suggest that hair cortisol and DHEA to cortisol ratio can be used as promising biomarkers of chronic stress among PLWH. Clarifying the role of steroid hormones in the psychoimmunology of PLWH may yield important implications for clinical practice and psychological intervention.

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Dataset Information

Seasonal variation in cortisol biomarkers in Hispanic mothers living in an agricultural region.

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Seasonal variation in cortisol biomarkers in Hispanic mothers living in an agricultural region.

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