Ontology highlight
ABSTRACT:
SUBMITTER: Ouyang S
PROVIDER: S-EPMC4851709 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
Ouyang Siwei S Song Yanfeng Y Tian Yingxia Y Chen Yibin Y Yu Xiaochun X Wang Degui D
Neurobiology of aging 20150711 10
The progressive loss of neurons causes neurodegenerative diseases. Because the accumulation of DNA breaks results in neuronal apoptosis, the lack of a variety of DNA damage repair-related proteins contributes to neurodegeneration. The ubiquitin ligase RNF8 plays an important role in DNA double-strand break repair via histone ubiquitination. However, the function of RNF8 in terminally differentiated neurons remains unknown. This study aimed to determine whether RNF8 is involved in the DNA damage ...[more]