Ontology highlight
ABSTRACT:
SUBMITTER: Wei M
PROVIDER: S-EPMC4859085 | biostudies-other | 2016 Jun
REPOSITORIES: biostudies-other
Wei Meng M Xie Qingyun Q Zhu Jun J Wang Tao T Zhang Fan F Cheng Yue Y Guo Dongyang D Wang Ying Y Mo Liweng L Wang Shuai S
Bioscience reports 20160506 3
CCL2-mediated macrophage infiltration in articular tissues plays a pivotal role in the development of the osteoarthritis (OA). miRNAs regulate the onset and progression of diseases via controlling the expression of a series of genes. How the CCL2 gene was regulated by miRNAs was still not fully elucidated. In the present study, we demonstrated that the binding sites of miR-33 in the 3'UTR of CCL2 gene were conserved in human, mouse and rat species. By performing gain- or loss-of-function studies ...[more]