Ontology highlight
ABSTRACT:
SUBMITTER: Cunha-Santos J
PROVIDER: S-EPMC4865854 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Cunha-Santos Janete J Duarte-Neves Joana J Carmona Vitor V Guarente Leonard L Pereira de Almeida Luís L Cavadas Cláudia C
Nature communications 20160511
Machado-Joseph disease (MJD) is a neurodegenerative disorder characterized by an abnormal expansion of the CAG triplet in the ATXN3 gene, translating into a polyglutamine tract within the ataxin-3 protein. The available treatments only ameliorate symptomatology and do not block disease progression. In this study we find that caloric restriction dramatically rescues the motor incoordination, imbalance and the associated neuropathology in transgenic MJD mice. We further show that caloric restricti ...[more]