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A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon.


ABSTRACT: We previously established that the expression of a thymic c-myb mRNA species requires the intermolecular recombination of coding sequences expressed from transcriptional units localized on different chromosomes, in both chicken and human. We now report that a putative splicing factor (PR264), extremely well conserved in chicken and human, is encoded by the opposite strand of the c-myb trans-spliced exon. The PR264 polypeptide, which contains a typical ribonucleoprotein 80 and an arginine/serine-rich domain, is highly homologous to the Drosophila splicing regulators tra, tra-2, and su(wa) and to the human alternative splicing factor ASF/SF2. Furthermore, we show that PR264-specific mRNAs are expressed in normal hematopoietic cells of chicken and human origin and that the relative proportion of the PR264 transcripts is developmentally regulated in chicken.

SUBMITTER: Vellard M 

PROVIDER: S-EPMC48691 | biostudies-other | 1992 Apr

REPOSITORIES: biostudies-other

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A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon.

Vellard M M   Sureau A A   Soret J J   Martinerie C C   Perbal B B  

Proceedings of the National Academy of Sciences of the United States of America 19920401 7


We previously established that the expression of a thymic c-myb mRNA species requires the intermolecular recombination of coding sequences expressed from transcriptional units localized on different chromosomes, in both chicken and human. We now report that a putative splicing factor (PR264), extremely well conserved in chicken and human, is encoded by the opposite strand of the c-myb trans-spliced exon. The PR264 polypeptide, which contains a typical ribonucleoprotein 80 and an arginine/serine-  ...[more]

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