Ontology highlight
ABSTRACT:
SUBMITTER: Abou-Samra AB
PROVIDER: S-EPMC48736 | biostudies-other | 1992 Apr
REPOSITORIES: biostudies-other
Abou-Samra A B AB Jüppner H H Force T T Freeman M W MW Kong X F XF Schipani E E Urena P P Richards J J Bonventre J V JV Potts J T JT
Proceedings of the National Academy of Sciences of the United States of America 19920401 7
Parathyroid hormone (PTH), a major regulator of mineral ion metabolism, and PTH-related peptide (PTHrP), which causes hypercalcemia in some cancer patients, stimulate multiple signals (cAMP, inositol phosphates, and calcium) probably by activating common receptors in bone and kidney. Using expression cloning, we have isolated a cDNA clone encoding rat bone PTH/PTHrP receptor from rat osteosarcoma (ROS 17/2.8) cells. The rat bone PTH/PTHrP receptor is 78% identical to the opossum kidney receptor; ...[more]