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Pancreatic cancer from bench to bedside: molecular pathways and treatment options.

ABSTRACT: In the last forty years the pancreatic cancer treatment has made advances, however; still novel drugs are needed. It is known that the five year survival rate remains around 5%. The best treatment option still remains surgery, if patients are diagnosed early. In the last decade the biology of pancreatic cancer has been vastly explored and novel agents such as; tyrosine kinase agents, or vaccines have been added as a treatment perspective. The big challenge is now to translate this knowledge in better outcomes for patients. In this current review we will present information from pancreatic cancer diagnosis to molecular pathways and treatment options; current and future.

SUBMITTER: Kosmidis C

PROVIDER: S-EPMC4876273 | biostudies-other | 2016 May

REPOSITORIES: biostudies-other

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Pancreatic cancer from bench to bedside: molecular pathways and treatment options.

Kosmidis Christoforos C Sapalidis Konstantinos K Kotidis Efstathios E Mixalopoulos Nikolaos N Zarogoulidis Paul P Tsavlis Drosos D Baka Sofia S Man Yan-Gao YG Kanellos John J

Annals of translational medicine 20160501 9

In the last forty years the pancreatic cancer treatment has made advances, however; still novel drugs are needed. It is known that the five year survival rate remains around 5%. The best treatment option still remains surgery, if patients are diagnosed early. In the last decade the biology of pancreatic cancer has been vastly explored and novel agents such as; tyrosine kinase agents, or vaccines have been added as a treatment perspective. The big challenge is now to translate this knowledge in b ...[more]

PMID: 27275478

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