Amyloid-? sequester proteins as blood-based biomarkers of cognitive decline.
Ontology highlight
ABSTRACT:
SUBMITTER: Uchida K
PROVIDER: S-EPMC4876892 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Publications
Amyloid-β sequester proteins as blood-based biomarkers of cognitive decline.
Uchida Kazuhiko K Shan Liu L Suzuki Hideaki H Tabuse Yo Y Nishimura Yoshinori Y Hirokawa Yoshihiro Y Mizukami Katsuyoshi K Akatsu Hiroyasu H Meno Kohji K Asada Takashi T
Alzheimer's & dementia (Amsterdam, Netherlands) 20150615 2
<h4>Introduction</h4>There are no blood-based biomarkers for cognitive decline in aging, or mild cognitive impairment (MCI) and Alzheimer's disease (AD). Cumulative evidence suggests that apolipoproteins, complement system, and transthyretin are involved in AD pathogenesis by sequestration of amyloid β. However, there is no clinical study to assess the utility of "sequester proteins" in risk assessment and/or diagnosis of MCI and AD.<h4>Methods</h4>Serum levels of sequester proteins and their cl ...[more]
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