Polymorphisms of the ELANE Gene Promoter Region in End-Stage Chronic Kidney Disease Patients.
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ABSTRACT:
SUBMITTER: Fernandes R
PROVIDER: S-EPMC4880837 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Publications
Polymorphisms of the ELANE Gene Promoter Region in End-Stage Chronic Kidney Disease Patients.
Fernandes Rafael R Freitas Bruno B Miranda Vasco V Costa Elísio E Santos-Silva Alice A Bronze-da-Rocha Elsa E
Genes 20160429 5
End-stage renal disease (ESRD) patients have a high mortality rate that exceeds that of non-ESRD population. The hemodialysis procedure induces neutrophil activation and elastase release, which might have a role in the inflammatory process and in the development of oxidative stress. The ELANE gene encodes the neutrophil elastase. We analyzed the effect of ELANE promoter region polymorphisms and its relation with the circulating levels of elastase, as well as several clinical, biochemical and inf ...[more]
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