Ontology highlight
ABSTRACT:
SUBMITTER: Hui TH
PROVIDER: S-EPMC4880901 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Hui T H TH Zhou Z L ZL Fong H W HW Ngan Roger K C RK Lee T Y TY Au Joseph S K JS Ngan A H W AH Yip Timothy T C TT Lin Y Y
Scientific reports 20160526
In this report, we showed that two tumor cell characteristics, namely the malignancy and drug-resistance status can be evaluated by their membrane resealing response. Specifically, membrane pores in a number of pairs of cancer and normal cell lines originated from nasopharynx, lung and intestine were introduced by nano-mechanical puncturing. Interestingly, such nanometer-sized holes in tumor cells can reseal ~2-3 times faster than those in the corresponding normal cells. Furthermore, the membran ...[more]