Ontology highlight
ABSTRACT:
SUBMITTER: Wank SA
PROVIDER: S-EPMC48817 | biostudies-other | 1992 Apr
REPOSITORIES: biostudies-other
Wank S A SA Harkins R R Jensen R T RT Shapira H H de Weerth A A Slattery T T
Proceedings of the National Academy of Sciences of the United States of America 19920401 7
The cholecystokinin (CCK) family of peptides and their receptors are widely distributed throughout the gastrointestinal and central nervous systems where they regulate secretion, motility, growth, anxiety, and satiety. The CCK receptors can be subdivided into at least two subtypes, CCKA and CCKB on the basis of pharmacological studies. We report here the purification of the CCKA receptor to homogeneity from rat pancreas by using ion-exchange and multiple affinity chromatographic separations. Thi ...[more]