Ontology highlight
ABSTRACT:
SUBMITTER: Zebedee SL
PROVIDER: S-EPMC48828 | biostudies-other | 1992 Apr
REPOSITORIES: biostudies-other
Zebedee S L SL Barbas C F CF Hom Y L YL Caothien R H RH Graff R R DeGraw J J Pyati J J LaPolla R R Burton D R DR Lerner R A RA
Proceedings of the National Academy of Sciences of the United States of America 19920401 8
Human antibody Fab fragments that bind to hepatitis B surface antigen (HBsAg) were generated by using a recombinant phage surface-display expression system. Characterization of HBsAg-specific Fab fragments isolated from two vaccinated individuals reveals diversity in specificity of antigen binding and in the sequences of the complementarity-determining region. The sequence results show examples of human light-chain promiscuity that result in fine specificity changes and a strong relationship to ...[more]