Ontology highlight
ABSTRACT:
SUBMITTER: McClenaghan C
PROVIDER: S-EPMC4886281 | biostudies-other | 2016 Jun
REPOSITORIES: biostudies-other
The Journal of general physiology 20160601 6
The TREK subfamily of two-pore domain (K2P) K(+) channels exhibit polymodal gating by a wide range of physical and chemical stimuli. Crystal structures now exist for these channels in two main states referred to as the "up" and "down" conformations. However, recent studies have resulted in contradictory and mutually exclusive conclusions about the functional (i.e., conductive) status of these two conformations. To address this problem, we have used the state-dependent TREK-2 inhibitor norfluoxet ...[more]