Associations between APOE polymorphisms and seven diseases with cognitive impairment including Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies in southeast China.

ABSTRACT: To explore the effect of APOE polymorphisms on patients with cognitive impairments in The Chinese Han population.A total of 1027 cases with Alzheimer's disease (AD), 40 cases with vascular dementia (VaD), 28 cases with behavioral variant frontotemporal dementia (bvFTD), 54 cases with semantic dementia (SD), 44 cases with dementia with Lewy bodies (DLB), 583 cases with mild cognitive impairment (MCI), and 32 cases with vascular cognitive impairment no dementia (VCIND) were recruited consecutively from memory disorders clinics in Huashan Hospital between January 2010 and December 2014. The 1149 cognitively normal controls were recruited from the community epidemiologic investigations. The APOE genotypes were determined using the TaqMan assay.The distribution of genotype and allele frequencies of APOE differed significantly between control and AD or MCI, with ?4 increasing the risk of AD and MCI in a dose-dependent pattern and ?2 decreasing the risk of AD, but not the risk of MCI. As for VaD, significant differences in the APOE genotype distribution were found compared with the controls. E4/4 increased the risk of VaD and ?4 increased the risk of VCIND in women. The allele distribution differed between bvFTD and controls, but genotype and allele frequencies of APOE did not affect the risk of bvFTD, SD, and DLB.In The Chinese Han population, APOE ?4 increased the risk of AD and MCI in a dose-dependent manner and ?2 decreased the risk of AD as reported previously. APOE ?4 might increase risk in VaD and female patients with VCIND, but no effects of APOE on bvFTD, DLB, and SD were found.

SUBMITTER: Chen KL 

PROVIDER: S-EPMC4890824 | biostudies-other | 2016 Jun

REPOSITORIES: biostudies-other