Ontology highlight
ABSTRACT:
SUBMITTER: Morris LG
PROVIDER: S-EPMC4891103 | biostudies-other | 2016 Mar
REPOSITORIES: biostudies-other
Morris Luc G T LG Riaz Nadeem N Desrichard Alexis A Şenbabaoğlu Yasin Y Hakimi A Ari AA Makarov Vladimir V Reis-Filho Jorge S JS Chan Timothy A TA
Oncotarget 20160301 9
As tumors accumulate genetic alterations, an evolutionary process occurs in which genetically distinct subclonal populations of cells co-exist, resulting in intratumor genetic heterogeneity (ITH). The clinical implications of ITH remain poorly defined. Data are limited with respect to whether ITH is an independent determinant of patient survival outcomes, across different cancer types. Here, we report the results of a pan-cancer analysis of over 3300 tumors, showing a varied landscape of ITH acr ...[more]