Ontology highlight
ABSTRACT:
SUBMITTER: Silveira-Dorta G
PROVIDER: S-EPMC4902051 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Beilstein journal of organic chemistry 20160512
An improved protocol for the synthesis of enantiomerically pure allylic amines is reported. N-Protected α-amino esters derived from natural amino acids were submitted to a one-pot tandem reduction-olefination process. The sequential reduction with DIBAL-H at -78 °C and subsequent in situ addition of organophosphorus reagents yielded the corresponding allylic amines without the need to isolate the intermediate aldehyde. This circumvents the problem of instability of the aldehydes. The method tole ...[more]