AMBRA1-induced mitophagy: A new mechanism to cope with cancer?

ABSTRACT: Dysfunctions in mitophagy, the process by which mitochondria are eliminated, are associated with cancer. We found that the proautophagic protein AMBRA1 (activating molecule in beclin 1 regulated autophagy) binds the autophagosome adapter LC3, and that this interaction is crucial for mitochondrial clearance with or without involvement of the E3-ligase PARKIN. The discovery of a novel mitophagy pathway has the potential to promote new anticancer strategies.

SUBMITTER: Strappazzon F 

PROVIDER: S-EPMC4904902 | biostudies-other | 2015 Apr-Jun

REPOSITORIES: biostudies-other