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Targeting the sumoylation pathway in cancer stem cells.


ABSTRACT: Cancer stem cells (CSCs) represent a subset of tumor cells with tumor-initiating potential. We recently demonstrated that inhibition of the sumoylation pathway cleared the CSC population and repressed the outgrowth of basal breast cancer xenografts. Targeting the sumoylation pathway offers a novel treatment strategy for basal breast cancer.

SUBMITTER: Bogachek MV 

PROVIDER: S-EPMC4905063 | biostudies-other | 2014 Jul-Sep

REPOSITORIES: biostudies-other

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