Ontology highlight
ABSTRACT:
SUBMITTER: Pillaire MJ
PROVIDER: S-EPMC4905163 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Pillaire Marie-Jeanne MJ Bétous Rémy R Hoffmann Jean-Sébastien JS
Molecular & cellular oncology 20140715 1
To ensure high cell viability and genomic stability, cells have evolved two major mechanisms to deal with the constant challenge of DNA replication fork arrest during S phase of the cell cycle: (1) induction of the ataxia telangiectasia and Rad3-related (ATR) replication checkpoint mechanism, and (2) activation of a pathway that bypasses DNA damage and DNA with abnormal structure and is mediated by translesion synthesis (TLS) Y-family DNA polymerases. This review focuses on how DNA polymerase ka ...[more]