Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140.
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ABSTRACT: Colon cancer frequently results from mutations that constitutively activate the Wnt signaling pathway, a major target being the tumor suppressor gene adenomatous polyposis coli (APC). We recently identified the transcription factor RIP140 as a new inducer of APC gene transcription that inhibits colon cancer cell growth and impedes the Wnt signaling pathway by reducing β-catenin activation.
SUBMITTER: Cavailles V
PROVIDER: S-EPMC4905177 | biostudies-other | 2014 Apr-Jun
REPOSITORIES: biostudies-other
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