Unknown

Dataset Information

0

Targeting tumor cell metabolism via the mevalonate pathway: Two hits are better than one.


ABSTRACT: Statins are promising anticancer agents that target the mevalonate pathway. Tumor cells are sensitive to depletion of mevalonate-derived products but this activity triggers a homeostatic feedback loop that blunts statin efficacy. We showed that dipyridamole inhibits this feedback response and potentiates statin antitumor activity. This study identifies statins plus dypridamole as a preclinically effective combination of approved agents.

SUBMITTER: Pandyra A 

PROVIDER: S-EPMC4905210 | biostudies-other | 2014 Oct-Dec

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC1948959 | biostudies-other
| S-EPMC6468620 | biostudies-literature
| S-EPMC4359330 | biostudies-other
| S-EPMC8137523 | biostudies-literature
| S-EPMC7472741 | biostudies-literature
| S-EPMC8464963 | biostudies-literature
| S-EPMC5600855 | biostudies-literature
| S-EPMC9340767 | biostudies-literature
2012-02-13 | E-GEOD-31812 | biostudies-arrayexpress