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SIN3B, the SASP, and pancreatic cancer.


ABSTRACT: Cellular senescence is classically considered a tumor suppressive mechanism. In addition to having stably exited the cell cycle, senescent cells secrete inflammatory factors. We recently demonstrated that senescence correlates with accelerated cancer progression in a mouse model of pancreatic ductal adenocarcinoma. Here, we discuss the implications of this study.

SUBMITTER: Cantor DJ 

PROVIDER: S-EPMC4905214 | biostudies-other | 2014 Oct-Dec

REPOSITORIES: biostudies-other

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