The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks.
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ABSTRACT: Transcription in the vicinity of DNA double-strand breaks (DSBs) is suppressed via a process involving ataxia telangiectasia mutated protein (ATM) and H2AK119 ubiquitylation.(1) We discuss recent findings that components of the Polybromo and Brahma-related gene 1 (BRG1)-associated factor (PBAF) remodeling complex and the polycomb repressive complex (PRC1/2) are also required.(2) Failure to activate transcriptional suppression impedes a rapid DSB repair process.
SUBMITTER: Kakarougkas A
PROVIDER: S-EPMC4905236 | biostudies-other | 2015 Jan-Mar
REPOSITORIES: biostudies-other
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