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TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling.


ABSTRACT: In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).

SUBMITTER: Salazar M 

PROVIDER: S-EPMC4905291 | biostudies-other | 2015 Jul-Sep

REPOSITORIES: biostudies-other

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