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SAT1 and glioblastoma multiforme: Disarming the resistance.


ABSTRACT: Glioblastoma multiforme is the most common and most detrimental form of brain tumor, with a current survival time of as little as 14 months. We have recently identified a novel mechanism of therapeutic resistance based on overexpression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase, which promotes DNA repair via chromatin modification.

SUBMITTER: Brett-Morris A 

PROVIDER: S-EPMC4905296 | biostudies-other | 2015 Jul-Sep

REPOSITORIES: biostudies-other

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