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ROS signaling during granzyme B-mediated apoptosis.


ABSTRACT: Reactive oxygen species (ROS) are involved in cell signaling, aging, and death and play a role in carcinogenesis. However, whether ROS are bystanders or active effectors of apoptosis was unclear until recently. New evidence shows that the killer lymphocyte protease granzyme B activates a conserved biochemical pathway centered on respiratory chain disruption to trigger mitocentric ROS-dependent apoptosis.

SUBMITTER: Martinvalet D 

PROVIDER: S-EPMC4905311 | biostudies-other | 2015 Jul-Sep

REPOSITORIES: biostudies-other

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