ROS signaling during granzyme B-mediated apoptosis.
Ontology highlight
ABSTRACT: Reactive oxygen species (ROS) are involved in cell signaling, aging, and death and play a role in carcinogenesis. However, whether ROS are bystanders or active effectors of apoptosis was unclear until recently. New evidence shows that the killer lymphocyte protease granzyme B activates a conserved biochemical pathway centered on respiratory chain disruption to trigger mitocentric ROS-dependent apoptosis.
SUBMITTER: Martinvalet D
PROVIDER: S-EPMC4905311 | biostudies-other | 2015 Jul-Sep
REPOSITORIES: biostudies-other
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