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AEG-1-AKT2: A novel complex controlling the aggressiveness of glioblastoma.


ABSTRACT: Expression of AEG-1 (also known as MTDH or LYRIC) is elevated in many cancers including glioblastoma multiforme (GBM), in which it functions as an oncogene. AEG-1 activates AKT signaling and physically interacts with AKT2 in GBM. Disruption of this interaction reduces glioma cell survival and invasion, uncovering a novel potential target for development of an effective therapy against GBM.

SUBMITTER: Emdad L 

PROVIDER: S-EPMC4905313 | biostudies-other | 2015 Jul-Sep

REPOSITORIES: biostudies-other

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