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Treating cancer when pRb and p53 cannot be reactivated.


ABSTRACT: Activation of oncoproteins and inactivation of tumor suppressors induces tumorigenesis. When these events happen upstream of pRb and p53, cancer therapies may initially succeed and then fail when pRb and p53 are activated and then re-inactivated. Therapies might succeed if they remain effective when pRb and p53 are genetically inactivated.

SUBMITTER: Zhu L 

PROVIDER: S-EPMC4905341 | biostudies-other | 2015 Oct-Dec

REPOSITORIES: biostudies-other

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