CHCHD2 connects mitochondrial metabolism to apoptosis.
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ABSTRACT: As the powerhouse of cells and gatekeeper for apoptosis, mitochondria control life and death. CHCHD2, a mitochondrial protein previously known to regulate metabolism, has recently been identified as an apoptosis inhibitor. New data suggest a model in which CHCHD2 performs a prosurvival function by acting as both a reactive oxygen species scavenger and BCL-XL activator.
SUBMITTER: Liu Y
PROVIDER: S-EPMC4905345 | biostudies-other | 2015 Oct-Dec
REPOSITORIES: biostudies-other
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