Ontology highlight
ABSTRACT:
SUBMITTER: Carter P
PROVIDER: S-EPMC49066 | biostudies-other | 1992 May
REPOSITORIES: biostudies-other
Carter P P Presta L L Gorman C M CM Ridgway J B JB Henner D D Wong W L WL Rowland A M AM Kotts C C Carver M E ME Shepard H M HM
Proceedings of the National Academy of Sciences of the United States of America 19920501 10
The murine monoclonal antibody mumAb4D5, directed against human epidermal growth factor receptor 2 (p185HER2), specifically inhibits proliferation of human tumor cells overexpressing p185HER2. However, the efficacy of mumAb4D5 in human cancer therapy is likely to be limited by a human anti-mouse antibody response and lack of effector functions. A "humanized" antibody, humAb4D5-1, containing only the antigen binding loops from mumAb4D5 and human variable region framework residues plus IgG1 consta ...[more]