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Nore1a drives Ras to flick the P53 senescence switch.

ABSTRACT: RAS-induced senescence is a protective mechanism to avoid unrestricted cell growth due to aberrant mitogenic signals; however, the exact mechanism by which RAS induces senescence is not known. We recently identified a novel pathway linking RAS to p53 via NORE1A and HIPK2 that mechanistically explains how Ras induces senescence.

SUBMITTER: Donninger H

PROVIDER: S-EPMC4909421 | biostudies-other | 2016 May

REPOSITORIES: biostudies-other

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