Unknown

Dataset Information

0

Ferroptosis: A missing puzzle piece in the p53 blueprint?


ABSTRACT: Recent evidence indicates that canonical functions of p53 (i.e., apoptosis and growth arrest) are dispensable for p53-mediated tumor suppression. We have uncovered a novel function of p53 that contributes to tumor suppression through regulation of cystine metabolism, reactive oxygen species responses, and ferroptosis. The p53-mediated ferroptotic response via SLC7A11 denotes an extra layer of defense against tumorigenesis in conjunction with other p53 functions.

SUBMITTER: Wang SJ 

PROVIDER: S-EPMC4909446 | biostudies-other | 2016 May

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC8637646 | biostudies-literature
| S-EPMC2566814 | biostudies-literature
2020-11-18 | GSE161688 | GEO
| S-EPMC9270610 | biostudies-literature
| S-EPMC3341047 | biostudies-other
| S-EPMC8881884 | biostudies-literature
| S-EPMC8284792 | biostudies-literature
| S-EPMC4053212 | biostudies-literature
| S-EPMC8713157 | biostudies-literature
| S-EPMC10631253 | biostudies-literature