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Ferroptosis: A missing puzzle piece in the p53 blueprint?


ABSTRACT: Recent evidence indicates that canonical functions of p53 (i.e., apoptosis and growth arrest) are dispensable for p53-mediated tumor suppression. We have uncovered a novel function of p53 that contributes to tumor suppression through regulation of cystine metabolism, reactive oxygen species responses, and ferroptosis. The p53-mediated ferroptotic response via SLC7A11 denotes an extra layer of defense against tumorigenesis in conjunction with other p53 functions.

SUBMITTER: Wang SJ 

PROVIDER: S-EPMC4909446 | biostudies-other | 2016 May

REPOSITORIES: biostudies-other

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