Ontology highlight
ABSTRACT:
SUBMITTER: Scheel AH
PROVIDER: S-EPMC4910698 | biostudies-other | 2016 May
REPOSITORIES: biostudies-other
Scheel Andreas H AH Ansén Sascha S Schultheis Anne M AM Scheffler Matthias M Fischer Rieke N RN Michels Sebastian S Hellmich Martin M George Julie J Zander Thomas T Brockmann Michael M Stoelben Erich E Groen Harry H Timens Wim W Perner Sven S von Bergwelt-Baildon Michael M Büttner Reinhard R Wolf Jürgen J
Oncoimmunology 20160316 5
Inhibition of the PD-1/PD-L1 pathway may induce anticancer immune responses in non-small cell lung cancer (NSCLC). Two PD-L1 immunohistochemistry (IHC) assays have been approved as companion diagnostic tests for therapeutic anti-PD-1 antibodies. However, many aspects of PD-L1 prevalence and association with genetically defined subtypes have not been addressed systematically. Here, we analyzed PD-L1 expression in 436 genetically annotated NSCLC specimens enriched for early stages using PD-L1 anti ...[more]