Ontology highlight
ABSTRACT:
SUBMITTER: Lamrani M
PROVIDER: S-EPMC4910700 | biostudies-other | 2016 May
REPOSITORIES: biostudies-other
Lamrani Myriam M Sassi Nejia N Paul Catherine C Yousfi Nadhir N Boucher Jean-Luc JL Gauthier Nolwenn N Labbé Jérôme J Seignez Cédric C Racoeur Cindy C Athias Anne A Guerreiro Romain R Vergely Catherine C Rochette Luc L Bettaieb Ali A Jeannin Jean-François JF
Oncoimmunology 20151229 5
Toll-like receptor (TLR) 4 agonists have emerged as a new group of molecules used for cancer therapy. They have been exploited to enhance the immunogenicity of current chemotherapeutic regimens. However, their effects on cancer cells remain elusive. Here, we showed that a TLR4 agonist, namely a synthetic lipid A analog (ALA), OM-174, exhibits antitumor effects in several mammary tumor mouse models. We also showed that immune components are involved in such effects, as attested to by the failure ...[more]