Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC4910909 | biostudies-other | 2016 May
REPOSITORIES: biostudies-other
Chen Xiaowan X Li Chenli C He Tiantian T Mao Jiating J Li Chunmei C Lyu Jianxin J Meng Qing H QH
Cancer biology & therapy 20160317 5
Metformin has been reported to inhibit the growth of various types of cancers, including prostate cancer. Yet the mode of anti-cancer action of metformin and the underlying mechanisms remain not fully elucidated. We hypothesized that the antitumorigenic effects of metformin are mediated through upregulation of pigment epithelium-derived factor (PEDF) expression in prostate cancer cells. In this report, metformin treatment significantly inhibited the proliferation and colony formation of prostate ...[more]