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Region-specific expression of a K+ channel gene in brain.

ABSTRACT: Northern blot analysis and in situ hybridization studies reveal the highly localized expression in rat brain of transcripts from a gene (KShIIIA) encoding components for voltage-gated K+ channels. KShIIIA expression is particularly prominent throughout the dorsal thalamus. The expression of KShIIIA is compared to that of a closely related gene, here called NGK2-KV4. These two genes encode transcripts that induce currents in Xenopus oocytes that are as of yet indistinguishable, but they show very different patterns of expression in rat brain. NGK2-KV4 transcripts are particularly abundant in the cerebellar cortex, where KShIIIA expression is very weak. These results demonstrate the existence of cell-type-specific K+ channel components and suggest that one reason for the unusually large diversity of K+ channel proteins is the presence of subtypes that participate in specific brain functions.

SUBMITTER: Rudy B

PROVIDER: S-EPMC49131 | biostudies-other | 1992 May

REPOSITORIES: biostudies-other

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Region-specific expression of a K+ channel gene in brain.

Rudy B B Kentros C C Weiser M M Fruhling D D Serodio P P Vega-Saenz de Miera E E Ellisman M H MH Pollock J A JA Baker H H

Proceedings of the National Academy of Sciences of the United States of America 19920501 10

Northern blot analysis and in situ hybridization studies reveal the highly localized expression in rat brain of transcripts from a gene (KShIIIA) encoding components for voltage-gated K+ channels. KShIIIA expression is particularly prominent throughout the dorsal thalamus. The expression of KShIIIA is compared to that of a closely related gene, here called NGK2-KV4. These two genes encode transcripts that induce currents in Xenopus oocytes that are as of yet indistinguishable, but they show very ...[more]

PMID: 1374908

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