CEACAM1-Mediated Inhibition of Virus Production.
Ontology highlight
ABSTRACT:
SUBMITTER: Vitenshtein A
PROVIDER: S-EPMC4914772 | biostudies-other | 2016 Jun
REPOSITORIES: biostudies-other
Publications
CEACAM1-Mediated Inhibition of Virus Production.
Vitenshtein Alon A Weisblum Yiska Y Hauka Sebastian S Halenius Anne A Oiknine-Djian Esther E Tsukerman Pinchas P Bauman Yoav Y Bar-On Yotam Y Stern-Ginossar Noam N Enk Jonatan J Ortenberg Rona R Tai Julie J Markel Gal G Blumberg Richard S RS Hengel Hartmut H Jonjic Stipan S Wolf Dana G DG Adler Heiko H Kammerer Robert R Mandelboim Ofer O
Cell reports 20160602 11
Cells in our body can induce hundreds of antiviral genes following virus sensing, many of which remain largely uncharacterized. CEACAM1 has been previously shown to be induced by various innate systems; however, the reason for such tight integration to innate sensing systems was not apparent. Here, we show that CEACAM1 is induced following detection of HCMV and influenza viruses by their respective DNA and RNA innate sensors, IFI16 and RIG-I. This induction is mediated by IRF3, which bound to an ...[more]
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