Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4914799 | biostudies-other | 2016 May
REPOSITORIES: biostudies-other
Wang Xingang X Zhang Yuxia Y Zhang Wei W Liu Haijun H Zhou Zewei Z Dai Xiaoniu X Cheng Yusi Y Fang Shencun S Zhang Yingming Y Yao Honghong H Chao Jie J
Toxicological sciences : an official journal of the Society of Toxicology 20160210 1
<h4>Background</h4>Silicosis is a fatal and fibrotic pulmonary disease caused by the inhalation of silica. After arriving at the alveoli, silica is ingested by alveolar macrophages (AMOs), in which monocyte chemotactic protein-induced protein 1 (MCPIP1) plays an essential role in controlling macrophage-mediated inflammatory responses. However, the mechanism of action of MCPIP1 in silicosis is poorly understood.<h4>Methods</h4>Primary rat AMOs were isolated and treated with SiO2 (50 µg/cm(2)). MC ...[more]