Wnt inhibition enhances browning of mouse primary white adipocytes.
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ABSTRACT:
SUBMITTER: Lo KA
PROVIDER: S-EPMC4916886 | biostudies-other | 2016 Apr-Jun
REPOSITORIES: biostudies-other
Publications
Wnt inhibition enhances browning of mouse primary white adipocytes.
Lo Kinyui Alice KA Ng Pei Yi PY Kabiri Zahra Z Virshup David D Sun Lei L
Adipocyte 20160322 2
The global epidemic in obesity and metabolic syndrome requires novel approaches to tackle. White adipose tissue, traditionally seen as a passive energy-storage organ, can be induced to take on certain characteristics of brown fat in a process called browning. The "browned" white adipose tissue, or beige fat, is a potential anti-obesity target. Various signaling pathways can enhance browning. Wnt is a key regulator of adipocyte biology, but its role in browning has not been explored. In this stud ...[more]
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