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Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts.

ABSTRACT: Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19?years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

SUBMITTER: Jelenkovic A 

PROVIDER: S-EPMC4917845 | biostudies-other | 2016 Jun

REPOSITORIES: biostudies-other

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Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts.

Jelenkovic Aline A   Sund Reijo R   Hur Yoon-Mi YM   Yokoyama Yoshie Y   Hjelmborg Jacob V B JV   Möller Sören S   Honda Chika C   Magnusson Patrik K E PK   Pedersen Nancy L NL   Ooki Syuichi S   Aaltonen Sari S   Stazi Maria A MA   Fagnani Corrado C   D'Ippolito Cristina C   Freitas Duarte L DL   Maia José Antonio JA   Ji Fuling F   Ning Feng F   Pang Zengchang Z   Rebato Esther E   Busjahn Andreas A   Kandler Christian C   Saudino Kimberly J KJ   Jang Kerry L KL   Cozen Wendy W   Hwang Amie E AE   Mack Thomas M TM   Gao Wenjing W   Yu Canqing C   Li Liming L   Corley Robin P RP   Huibregtse Brooke M BM   Derom Catherine A CA   Vlietinck Robert F RF   Loos Ruth J F RJ   Heikkilä Kauko K   Wardle Jane J   Llewellyn Clare H CH   Fisher Abigail A   McAdams Tom A TA   Eley Thalia C TC   Gregory Alice M AM   He Mingguang M   Ding Xiaohu X   Bjerregaard-Andersen Morten M   Beck-Nielsen Henning H   Sodemann Morten M   Tarnoki Adam D AD   Tarnoki David L DL   Knafo-Noam Ariel A   Mankuta David D   Abramson Lior L   Burt S Alexandra SA   Klump Kelly L KL   Silberg Judy L JL   Eaves Lindon J LJ   Maes Hermine H HH   Krueger Robert F RF   McGue Matt M   Pahlen Shandell S   Gatz Margaret M   Butler David A DA   Bartels Meike M   van Beijsterveldt Toos C E M TC   Craig Jeffrey M JM   Saffery Richard R   Dubois Lise L   Boivin Michel M   Brendgen Mara M   Dionne Ginette G   Vitaro Frank F   Martin Nicholas G NG   Medland Sarah E SE   Montgomery Grant W GW   Swan Gary E GE   Krasnow Ruth R   Tynelius Per P   Lichtenstein Paul P   Haworth Claire M A CM   Plomin Robert R   Bayasgalan Gombojav G   Narandalai Danshiitsoodol D   Harden K Paige KP   Tucker-Drob Elliot M EM   Spector Timothy T   Mangino Massimo M   Lachance Genevieve G   Baker Laura A LA   Tuvblad Catherine C   Duncan Glen E GE   Buchwald Dedra D   Willemsen Gonneke G   Skytthe Axel A   Kyvik Kirsten O KO   Christensen Kaare K   Öncel Sevgi Y SY   Aliev Fazil F   Rasmussen Finn F   Goldberg Jack H JH   Sørensen Thorkild I A TI   Boomsma Dorret I DI   Kaprio Jaakko J   Silventoinen Karri K  

Scientific reports 20160623

Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood  ...[more]