Ontology highlight
ABSTRACT:
SUBMITTER: Crabtree JN
PROVIDER: S-EPMC4918823 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
Crabtree Juliet N JN He Wenqian W Guan Weihua W Flage Mark M Miller Matthew S MS Peterson Erik J EJ
The Journal of infectious diseases 20160330 2
High-affinity-antibody production, T-cell activation, and interferon upregulation all contribute to protective immunity that occurs in humans following influenza immunization. Hematopoietic cell-specific PTPN22 encodes lymphoid phosphatase (Lyp), which regulates lymphocyte antigen receptor and pattern recognition receptor (PRR) signaling. A PTPN22 variant, R620W (LypW), predisposes to autoimmune and infectious diseases and confers altered signaling through antigen receptors and PRRs. We tested t ...[more]