Ontology highlight
ABSTRACT:
SUBMITTER: Lu YC
PROVIDER: S-EPMC4921817 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Lu Yong Chao YC Yang Jing J Fok Kin Lam KL Ye Ying Hui YH Jin Liang L Chen Zheng Yun ZY Zhang Xin Mei XM Huang He Feng HF Chan Hsiao Chang HC
Scientific reports 20160627
Bicarbonate (HCO3(-)) is essential for preimplantation embryo development. However, the mechanism underlying the HCO3(-) transport into the embryo remains elusive. In the present study, we examined the possible involvement of Cl(-)/HCO3(-) exchanger in mediating HCO3(-) transport into the embryo. Our results showed that depletion of extracellular Cl(-), even in the presence of HCO3(-), suppressed embryo cleavage in a concentration-dependent manner. Cleavage-associated HCO3(-)-dependent events, i ...[more]