Ontology highlight
ABSTRACT:
SUBMITTER: Kotamraju VR
PROVIDER: S-EPMC4924884 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Kotamraju Venkata Ramana VR Sharma Shweta S Kolhar Poornima P Agemy Lilach L Pavlovich James J Ruoslahti Erkki E
Breast cancer : basic and clinical research 20150101 Suppl 2
Tumor-homing peptides with tissue-penetrating properties increase the efficacy of targeted cancer therapy by delivering an anticancer agent to the tumor interior. LyP-1 (CGNKRTRGC) and iRGD (CRGDKGPDC) are founding members of this class of peptides. The presence of the cysteines forming the cyclizing disulfide bond complicates conjugation of these peptides with other molecules, such as drugs. Here, we report the synthesis of conjugatable disulfide-bridged peptides and their conjugation to biolog ...[more]