Ontology highlight
ABSTRACT:
SUBMITTER: Pan F
PROVIDER: S-EPMC4928080 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Pan Feiyan F Zhao Jing J Zhou Ting T Kuang Zhihui Z Dai Huifang H Wu Huan H Sun Hongfang H Zhou Xiaolong X Wu Xuping X Hu Zhigang Z He Lingfeng L Shen Binghui B Guo Zhigang Z
Scientific reports 20160630
DNA polymerase β (Pol β), a key enzyme in the DNA base excision repair (BER) pathway, is pivotal in maintaining the integrity and stability of genomes. One Pol β mutation that has been identified in tumors, R137Q (arginine to glutamine substitution), has been shown to lower polymerase activity, and impair its DNA repair capacity. However, the exact functional deficiency associated with this polymorphism in living organisms is still unknown. Here, we constructed Pol β R137Q knock-in mice, and fou ...[more]