Ontology highlight
ABSTRACT:
SUBMITTER: Roffman JL
PROVIDER: S-EPMC4928887 | biostudies-other | 2016 Jun
REPOSITORIES: biostudies-other
Science advances 20160603 6
Local prefrontal dopamine signaling supports working memory by tuning pyramidal neurons to task-relevant stimuli. Enabled by simultaneous positron emission tomography-magnetic resonance imaging (PET-MRI), we determined whether neuromodulatory effects of dopamine scale to the level of cortical networks and coordinate their interplay during working memory. Among network territories, mean cortical D1 receptor densities differed substantially but were strongly interrelated, suggesting cross-network ...[more]