Ontology highlight
ABSTRACT:
SUBMITTER: De Lorenzi V
PROVIDER: S-EPMC4931562 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
De Lorenzi Valentina V Sarra Ferraris Gian Maria GM Madsen Jeppe B JB Lupia Michela M Andreasen Peter A PA Sidenius Nicolai N
EMBO reports 20160517 7
Components of the plasminogen activation system including urokinase (uPA), its inhibitor (PAI-1) and its cell surface receptor (uPAR) have been implicated in a wide variety of biological processes related to tissue homoeostasis. Firstly, the binding of uPA to uPAR favours extracellular proteolysis by enhancing cell surface plasminogen activation. Secondly, it promotes cell adhesion and signalling through binding of the provisional matrix protein vitronectin. We now report that uPA and plasmin in ...[more]